Cannabis in molecules: THCa (Eng)
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Cannabis in molecules: THCa (Eng)


The main constituent of the Cannabis plant
in its raw, unheated form is D9-THCA, thetrahydrocannabinol acid In the Cannabis plant, the cannabinoids are
synthesised and stored in their acidic state. The peculiar chemical composition of cannabinoid
acids make them devoid of psychotropic effects Only upon heating of the plant, through a chemical process that is defined in chemistry as
decarboxylation, the molecules are reduced to phenols, which produce the
mind-altering effects typically associated with
consumption of heated cannabis such as vaporised or smoked cannabis. That is, the raw plant in its natural state mainly contains THCA and CBDA, which are converted almost entirely onto THC and CBD only once
heated at least at 100 degree Celsius. The primary actions of THCA are mediated through
receptors that are deputed to the control of pain,
inflammation and temperature, such as TRPA1 and TRPM8. Once THCA has been absorbed in the system, it activates a receptor that is called
TRPA1. TRPA1 is responsible for immune and analgesic response. You can think of TRPA1 as an ambulance siren,
that is calling out for the required staff to act
quickly and sensibly for providing survival of the patient. THCA acts also via other receptors, such as
TRPM8, which is commonly identified as the cold and menthol receptor. THCA blocks TRPM8, which is considered a key step for inhibiting the survival and growth of prostate
cancer cells. THCA also binds weakly with the cannabinoid
receptors CB1 and CB2, when compared to THC, and does not cross the Blood Brain Barrier. Since it does not have access to the cannabinoid
receptors CB1 present in the brain, it does not induce the effects typically associated with the consumption of THC such as increased appetite, euphoria, paranoia, or sedative states. Thus, THCA binds with the cannabinoid receptors
present at the periphery of the body, such as GPR55, CB2 and, at less extent, CB1. Via these receptors it mediates anti-prolific action
(that is, pro-apoptotic, easing cellular death of diseased cells, such as
cancer cells). It also has anti-spasmodic and antibiotic actions. THCA is a safe substance that can be intaken
at large quantities without provoking mind-altering intoxicating effects; it is therefore suggested to anyone
who requires an aid to their immune system, including pregnant women, elders and children. THCA can be consumed via cold extraction,
for example via a slow juicing of fresh leafs and flowers of the Cannabis plant. It is highly recommended as dietary supplement
for prevention and treatment of inflammatory conditions. In summary, it is used for the following medical
benefits: analgesia (it’s advised to whom suffer from
chronic and neuropathic pain) antibiotic (it is used in veterinary as well
as dentistry) anti-emetic (reduces nausea and vomit)
anti-inflammatory (it’s used by Lupus patients, as well as diabetes, MS and ALS patients)
anti-proliferative (it exerts anti-tumoral activities, particularly targeting prostate,
breast, stomach, rectum and leukemia type of cancers). These data derive from in vitro studies as
well as anecdotal data from patients self-medicating with cannabis juice. THCA antitumoral actions are important, but
has not been found suitable as unique therapy in the later stages of a cancer, for which
THC and CBD extracts are highly advised. You can check out here, there is another video about cannabis oils and extracts for cancer therapy. It’s also an anti-spastic,
is hence important in the management of disorders that induce muscular spasms, such as Parkinson’s,
MS and ALS. It is a neuroprotectant, prevents degradation of neural
cells, slowing the sight, hearing and cognitive decrease associated with ageing. If you are interested in knowing more about cannabinoids acids we have a project that is called Raw, you can check it out here or I’ll put a link below, it’s therawstudy.eu and we promote clinical trials with raw cannabis juicing for, so far, Multiple Sclerosis but we really wish to extend this to others disorders. Otherwise, you can check out on naturegoingsmart.com articles that review in much more details the beneficial effects of cannabis juicing.

6 thoughts on “Cannabis in molecules: THCa (Eng)

  1. è possibile avere una versione in italiano di questo video? oppure mi potreste dire dove posso trovare queste informazioni, ovviamente sempre in italiano? grazie

  2. sorry if I missed it, so do I need to decarboxylate the cannabis leaves, bud etc to make a cancer curing oil?

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