Inside ALS: The neurons behind the disease
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Inside ALS: The neurons behind the disease


amyotrophic Lateral sclerosis Shortened to Als is a neurodegenerative disease Which usually begins in adulthood and Advances rapidly? It’s characterized by the deterioration and loss of both upper and lower motor Neurons as the motor Neurons stop sending signals the Muscles weaken leading to Paralysis When the muscles in the diaphragm are paralyzed this can be fatal. There is no known cure for Als For most people the cause of their lS is unknown, but some people inherit the disease from their parents By studying the genes that are altered in these patients scientists have pinpointed processes in the neurons that might be causing als It’s too early to [know] which of these altered processes are a result of the disease and which could be a cause But it’s clear that they affect many different aspects of the motor neuron function Let’s start in the cell body here proteins that are not transported into the nucleus build up in the cytoplasm Errors in the systems that build up and break down proteins also cause other [Misfolded] proteins to accumulate The different proteins can then aggregate and can become toxic to cells in Several ways For example they can damage mitochondria the cell’s power generators Mitochondrial damage can lead to oxidative stress which can trigger breaks in the dNA of the cell Als seems to affect Dna repair processes as well When Dna breaks are poorly repaired it ultimately contributes to the death of the neuron? the cells Transport Machinery can also be damaged For example [als] affected neurons often have problems Transporting rnA proteins and vesicles Both in the cytoplasm and along the neurons axon these vesicles containing [Pourtant] cell signaling molecules called neurotransmitters If these can’t be moved along the axon or released the neuron can’t send messages to its target cells damage to the cytoskeleton can also cause the Axon to retract [if] This happens the Axon can no longer connect to the muscle nearby and can no longer signal the muscle to contract other cell types can also be involved in als Oligodendrocytes which electrically insulate the axon and [provide] support to the motor neuron don’t work in people with Als reduced uptake of Neurotransmitters by astrocytes can lead to over activation of the receptors at the synapse and death of the neuron Finally astrocytes and Microglia can produce factors that protect or [damaged] motor neurons Neuronal death occurs when excessive damaging factors are produced Further research is needed to find out which of these many processes caused the motor neuron degeneration seen in als patients Targeting new drug therapies at those processes might lead to a treatment for this incurable disease

35 thoughts on “Inside ALS: The neurons behind the disease

  1. are these protein aggregates the same as the protein aggregates responsible for Parkinson disease? (α-synuclein and some other proteins.)

  2. I'm happy because everyday more people are searching for a cure for ALS. Thanks Nature for your video, was very illustrative.

  3. This is literally the best channel I've ever come across on Youtube. The amount of detail and the visual complements are just incredible.

  4. depth of content worthy of nature journal. however agreeing with another commenter that key questions are skipped, why does it only affect motor neurons etc, which could have been touched on by one sentence, e.g. it's not clear whether. That could have improved the quality of the video tremendously

  5. So many ways of neurodegeneration and we don't know which one/s are the problem here or in other neurodegenerative diseases such as Alzheimer's – why is there so little research?

  6. سر میں پاکستان سے ھوں mnd ALS کامریض ھوں 2سال ھو گئےہیں چل نہین سکھتا ھوں بول بھی نہیں سکھتا ھوں اللہ تعالی کے واسطے جواب دے

  7. miglior anticoagulante , senza alcun effetto collaterale rigetto, a costo zero, Primum No Nocere, Ippocrate, e sicuramente a potenziamento del Warfarin-Coumadin , con dosaggi sicuramente inferiori di molto e liglior fluidificazione sangue, arricchito, a livello di IONI-Atomi, di tutti i minerali-oligoelementi-Plancton marino, aminoacidi-vitamine_ormoni, senza alcun effetto collaterale-rigetto, Primum No Nocere, Ippocrate, in linea assoluta con il Nobel Medicina,anno 1912, Alexis Carrel . https://www.facebook.com/notes/francesco-paolo-ruggieri/mia-bevanda-alcalina-osso-sepia-alexis-carrel-lpaulingvpantellinitsimoncinielisi/826377524042392/

  8. miglior anticoagulante , senza alcun effetto collaterale rigetto, a costo zero, Primum No Nocere, Ippocrate, e sicuramente a potenziamento del Warfarin-Coumadin , con dosaggi sicuramente inferiori di molto e miglior fluidificazione sangue, arricchito, a livello di IONI-Atomi, di tutti i minerali-oligoelementi-Plancton marino, attivatori di tutti gli ENZIMI cellulari e ossigenatore cellule, quindi ripresa funzionalità die NEURONI, aminoacidi-vitamine_ormoni, senza alcun effetto collaterale-rigetto, Primum No Nocere, Ippocrate, in linea assoluta con il Nobel Medicina,anno 1912, Alexis Carrel . https://www.facebook.com/notes/francesco-paolo-ruggieri/mia-bevanda-alcalina-osso-sepia-alexis-carrel-lpaulingvpantellinitsimoncinielisi/826377524042392/

  9. (MUST READ)
    I was diagnosed of ALS (Amyotrophic Lateral Sclerosis) 2016 at Parkland hospital, Dallas. Where i was given medications to help my symptoms. In August 2017 my symptoms worsened, with no hope of a cure from the hospital i looked out for an alternative treatment. I read on a website about Perfect Cure Herbal Clinic and their successful herbal treatment for ALS and some other viruses, i immediately contacted them via their E-mail and purchased the ALS herbal remedy. I used the herbal remedy for 9 weeks, all my symptoms including difficulty in walking, weakness in legs and arm, slurred speech etc miraculously disappeared, my speech is understandable now, its unbelievable.
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  10. The diaease of addiction. Addiction from stimulants. Stop before its too late. I seen friends change due to this disease . Be strong. Man made . it didn't make man .

  11. very scary ii Have a Question ii Have to ReSearch more it's Been about 4🌎 Days Now My Left ✋ Hand Feel very Numb Numb and can't pick up a cup of water Not to Good But I Have Noo pain i Think i Got to make a Doctor appointment

    ii Remember My Favorite TvShow of StarGate Universe and The Nurse Got that aLs disease inn the TvShow and she was washing clothes and Rub Her ✋ Hand it Look Like? she was pain ???

    iiiiiiiii am scared of Doctors i didn't seen one when i was the age of 18 and Going to Be 30 in 8-18-88

  12. HOW I GOT CURED OF ALS
    I was diagnosed with ALS (amyotrophic lateral sclerosis) 10 months ago. At that time Rilutek (riluzole) was prescribed. I found I could not tolerate it. I have tried it again 3 months ago with the same result. I am so fortunate that my progression seems to be very slow until I got to know about Dr. Sani herbal cure and decided to give it a try, today I am completely cured and since then I haven't had any symptoms of ALS again, and my doctor also confirmed me totally free from ALS, and he said it could only be a miracle. My arms and legs are in perfect conditions and I can talk very well now. I have a great doctor and a team of wonderful people who helped me during this period of getting cured. Most of all, my wife and Dr. Sani that cured me. God bless you greatly.
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  13. Relax! – ALS can be Wiped Out in less than a month along with Multiple Sclerosis, any other Neurodegenerative and Any Other Diseases [Cancers, Diabetes, Infections (HIV/AIDS, Colds, Flues, Malaria, Ebola, Yellow Fever, etc.), Polio, TB, Cardiovascular, Cerebrovascular, Genetic, Chronic, Autoimmune, etc.], everybody will become Infinitely Healthy and by that – Immortal, for Infinite Health = Immortality (8,500 years guaranteed) – By doing juts an exercise for a minute a day, that cures and prevents any Diseases, known on Earth, even Aging and Radiation Disease, for every cell of our bodies is shielded 100% from any external/internal (genetic) detrimental impact (any Viruses and any other Pathogens are killed the moment they touch us) – Doing this exercise for just a minute a day, in less than a month everybody will become Infinitely Healthy, Radiation-Proof and Immortal – Like the Gods who created us humans – I will describe my Discovery to everyone, who sends me an E-check for One Thousand US Dollars.

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  15. My Husband was diagnosed with ALS (Lou Gehrig's Disease) when he
    was 62 years old 4 years ago. The Rilutek (riluzole) did very little to
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  16. My mom have this ALS since 2007 to present. the doctor said before she's only got 3years and luckily she's with us until now. 12years since then and i hope more and more years to come for my mother :'(

  17. Proteins that build up are what's causing the traffic jam into the nuclear port. Maybe start by finding which protein and use an antibody to remove them, also maybe find a way to sneak past the nuclear port thus minimizing congestion. Wish I was a scientist, instead I'm a hairstylist.

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