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What happens when your DNA is damaged? – Monica Menesini

The DNA in just one of your cells gets damaged tens of thousands of times per day. Multiply that by your body’s hundred trillion or so cells, and you’ve got a quintillion DNA errors everyday. And because DNA provides the blueprint for the proteins your cells need to function, damage causes serious problems, such as […]

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Your Textbooks Are Wrong, This Is What Cells Actually Look Like

I still remember the moment. That’s something that I will never forget. The hair on my hands just stood up. It’s a microscopic universe within each cell. This is an unprecedented view of the cellular world, where we can actually see immune cells scooping up sugars in the ear of a zebrafish in real time. […]

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Two Minute Talk – Video Abstract for Leaver et al, Biology Open 2016.

Hi, my name is Mark Leaver, and today I’m going to be talking about work that my colleagues and I recently published in the journal Biology Open. I’m interested in the genetics of how organisms adapt to higher temperatures, and I’ve chosen to study this in the nematode Pristionchus pacificus for 3 reasons: it’s cold-blooded, […]

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Cancer cell biology: mutated KRAS & reciprocal signalling

Tumours contain lots of different cells. Apart from the cancer cells, a tumour can also include immune cells and stromal fibroblasts. In pancreatic cancer a protein called KRAS is often mutated. Healthy KRAS occasionally sends a message that tells the cell to divide. When KRAS is mutated, it becomes hyperactive and can’t switch off any […]

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