Virtual Physiological Human | Wikipedia audio article
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Virtual Physiological Human | Wikipedia audio article

The Virtual Physiological Human (VPH) is a
European initiative that focuses on a methodological and technological framework that, once established,
will enable collaborative investigation of the human body as a single complex system. The collective framework will make it possible
to share resources and observations formed by institutions and organizations, creating
disparate but integrated computer models of the mechanical, physical and biochemical functions
of a living human body. VPH is a framework which aims to be descriptive,
integrative and predictive. Clapworthy et al. state that the framework
should be descriptive by allowing laboratory and healthcare observations around the world
“to be collected, catalogued, organized, shared and combined in any possible way.” It should be integrative by enabling those
observations to be collaboratively analyzed by related professionals in order to create
“systemic hypotheses.” Finally, it should be predictive by encouraging
interconnections between extensible and scalable predictive models and “systemic networks that
solidify those systemic hypotheses” while allowing observational comparison.The framework
is formed by large collections of anatomical, physiological, and pathological data stored
in digital format, typically by predictive simulations developed from these collections
and by services intended to support researchers in the creation and maintenance of these models,
as well as in the creation of end-user technologies to be used in the clinical practice. VPH models aim to integrate physiological
processes across different length and time scales (multi-scale modelling). These models make possible the combination
of patient-specific data with population-based representations. The objective is to develop a systemic approach
which avoids a reductionist approach and seeks not to subdivide biological systems in any
particular way by dimensional scale (body, organ, tissue, cells, molecules), by scientific
discipline (biology, physiology, biophysics, biochemistry, molecular biology, bioengineering)
or anatomical sub-system (cardiovascular, musculoskeletal, gastrointestinal, etc.).==History==
The initial concepts that led to the Virtual Physiological Human initiative came from the
IUPS Physiome Project. The project was started in 1997 and represented
the first worldwide effort to define the physiome through the development of databases and models
which facilitated the understanding of the integrative function of cells, organs, and
organisms. The project focused on compiling and providing
a central repository of databases that would link experimental information and computational
models from many laboratories into a single, self-consistent framework. Following the launch of the Physiome Project,
there were many other worldwide initiatives of loosely coupled actions all focusing on
the development of methods for modelling and simulation of human pathophysiology. In 2005, an expert workshop of the Physiome
was held as part of the Functional Imaging and Modelling of the Heart Conference in Barcelona
where a white paper entitled Towards Virtual Physiological Human: Multilevel modelling
and simulation of the human anatomy and physiology was presented. The goal of this paper was to shape a clear
overview of on-going relevant VPH activities, to build a consensus on how they can be complemented
by new initiatives for researchers in the EU and to identify possible mid-term and long
term research challenges. In 2006, the European Commission funded a
coordination and support action entitled STEP: Structuring The EuroPhysiome. The STEP consortium promoted a significant
consensus process that involved more than 300 stakeholders including researchers, industry
experts, policy makers, clinicians, etc. The prime result of this process was a booklet
entitled Seeding the EuroPhysiome: A Roadmap to the Virtual Physiological Human. The STEP action and the resulting research
roadmap were instrumental in the development of the VHP concept and in the initiation of
much larger process that involves significant research funding, large collaborative projects,
and a number of connected initiatives, not only in Europe but also in the United States,
Japan, and China. VPH now forms a core target of the 7th Framework
Programme of the European Commission, and aims to support the development of patient-specific
computer models and their application in personalised and predictive healthcare. The Virtual Physiological Human Network of
Excellence (VPH NoE) aims to connect the various VPH projects within the 7th Framework Programme.==Goals of the initiative==
VPH-related projects have received substantial funding from the European Commission in order
to further scientific progress in this area. The European Commission is insistent that
VPH-related projects demonstrate strong industrial participation and clearly indicate a route
from basic science into clinical practice. In the future, it is hoped that the VPH will
eventually lead to a better healthcare system which aims to produce the following benefits:
personalized care solutions reduced need for experiments on animals
more holistic approaches to medicine preventative approaches to treatment of diseasePersonalized
care solutions are a key aim of the VPH, with new modelling environments for predictive,
individualized healthcare to result in better patient safety and drug efficacy. It is anticipated that the VPH could also
result in healthcare improvement through greater understanding of pathophysiological processes. The use of biomedical data from a patient
to simulate potential treatments and outcomes could prevent the patient from experiencing
unnecessary or ineffective treatments. The use of in silico (by computer simulation)
modelling and testing of drugs could also reduce the need for experiments on animals. A future goal is that there will be also be
a more holistic approach to medicine with the body treated as a single multi-organ system
rather than as a collection of individual organs. Advanced integrative tools should further
help to improve the European healthcare system on a number of different levels that include
diagnosis, treatment and care of patients and in particular quality of life.==Projects==
ImmunoGrid is a project funded by the EU under Framework 6, to model and simulate the human
immune system using grid computing at different physiological levels.==See also==
Cytome EuroPhysiome
Human anatomy Living Human Project
Physiology Physiome
Virtual Physiological Rat VPHOP (Osteoporotic Virtual Physiological

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