What is Genomic Sequencing?
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What is Genomic Sequencing?



genomic sequencing is a process for analyzing a sample of DNA taken from your blood in the lab technicians extract DNA and prepare it for sequencing within every normal cell are 23 pairs of chromosomes chromosomes are structures that house DNA DNA is coiled into a shape called the double helix the double helix can be unwound into a ladder shape the ladder is made up of paired chemical letters called bases altogether our DNA contains about 6 billion such paired chemical bases there are 4 bases in the DNA alphabet a T C and G in DNA base a joins only with base T and base G joins only with base C to read the sequence of bases in DNA samples are inserted into a sequencing instrument where high-frequency sound waves break the DNA into smaller pieces that are only about 600 bases long special tags are added to the ends of the fragmented DNA these tagged strands of DNA can then attach to a glass slide in a sequencer each piece of DNA is copied hundreds of thousands of times which creates clusters of identical DNA fragments next the sequencer reads the DNA one base at a time using different colored tags for each DNA base special sensors within the machine detect the different colored tags this sequence of colors reveals the DNA sequence of each fragment powerful computers piece together these individual DNA fragments and reveal the sequence of your DNA then a team of medical experts uses specialized software to analyze and compare the DNA sequences to identify the handful of variants that may be important for your medical care discuss the results of the sequencing of your DNA with your doctor and a genetic counselor you

2 thoughts on “What is Genomic Sequencing?

  1. This can probably identify several known SNPs associated with certain genetic diseases. However correlating a mutation to a physical effect or a disease is more complicated. Many diseases are polygenic and results of these mutations manifest differently in different individuals depending on other mutations on many other genes, environment and epigenetic status. Even then there are many well known associations which are useful in one's decision buying a good health insurance.    Remember, most of us harbor several of the known oncogenic DNA sequences or mutations and translocations at least in one cell but still do not get cancer. 

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