What is Supercoiling in DNA?
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What is Supercoiling in DNA?


Transcription can lead to supercoiling,
essentially what supercoiling is the double helix twisting so much so that it
coils onto itself. When you want to transcribe two genes on the same piece
of DNA it leads to two types of supercoiling,
positive and negative. Positive supercoiling is putting so much tension
on the double helix that it makes it harder to transcribe the gene. Negative
supercoiling puts less tension on the double helix making it much easier to
transcribe the gene. This means that supercoiling makes transcription a lot less
predictable.

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