Your Textbooks Are Wrong, This Is What Cells Actually Look Like
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Your Textbooks Are Wrong, This Is What Cells Actually Look Like


I still remember the moment. That’s something
that I will never forget. The hair on my hands just stood up. It’s a microscopic universe
within each cell. This is an unprecedented view of the cellular world, where we can actually
see immune cells scooping up sugars in the ear of a zebrafish in real time. Focusing
only on the crawling immune cells, we’ve noticed two classes of them. One, it seems was not
hungry at all, but it was very active in terms of trying to figure out what the environment
is. But there was another one that was slouching around with a lot of food in its belly. We
can actually conceptualize, visualize, and analyze the contents of each of these cellular
compartments in this crawling immune cell as it’s scooping up its environment. That
is a level of detail no one’s ever seen before. We’re living in a new era of cell
biology, where microscopy advancements are giving biologists the opportunity to reveal
the hidden patterns of cells. What we expect to learn from here on out will transform our
understanding of human health and rewrite the textbooks on the fundamental unit of life. For centuries, microscopes have illuminated previously invisible worlds. We’ve learned
how cells divide and even discovered the existence of bacteria and microorganisms. These historical
breakthroughs are often found in your typical high school textbook. I fell in love with
the cell and wanting to understand the cell when I saw textbook images. I learned as I
started studying the cell, that those are vast simplifications of what those structures
actually do and what’s inside the cell. They don’t allow us to embrace the messiness and
complexity in the cell. At research organizations like the Allen Institute for Cell Science, biologists
are taking a more integrated view to better understand this complexity. So we at the
Institute are trying to think of all the structures of the cells in a holistic manner. If we don’t
understand which parts of the cell interact with which other ones we won’t ever be able
to understand the true mode of action of a drug, or perhaps where the side effects come
from. It’s that integrated knowledge of how when you pull here, you move there, that allows
us to understand the cell or the tissue or the organism properly. And if you don’t do
that you’re going to miss really important things. In order to see the patterns that
are actually happening in the cell in space and time, we have to be able to image the
cell well in space and time. New microscopy is what’s allowing us to image a cell in three
dimensions, in their native context without killing and hurting the cells, which is just absolutely needed for us to just study the cell as it is. But
seeing biological processes inside living samples without harming them is easier said
than done. One of the ways scientists image these dynamics is with fluorescence microscopy.
However, harsh light from this technique can cause phototoxicity, meaning the cell can
get sick during the imaging session. Lattice light-sheet microscopy was invented a few
years ago to correct for that challenge. So it’s a non-diffracting beam, meaning that
as the beam is traversing through the sample, it’s not converging or diverging. We put
several of these at very specific positions such that you interfere every beam with itself
and then create a very thin sheet of light. This fine sheet of light repeatedly sweeps
over a sample in order to avoid the damage that’s typically associated with other microscopy
techniques. The result builds a high resolution 3D movie depicting relatively undisturbed
living cells functioning over time. But tissues and other biological structures surrounding
cells tend to scramble the light from the microscope, resulting in blurriness. To compensate
for this, the same team behind the lattice light-sheet microscope borrowed a trick astronomers
use to get clear views of distant stars – adaptive optics. Just like how astronomers use lasers
as “guide stars” to course correct blurriness in telescopes, the process for looking at
the infinitesimally small world of cells through thick tissues and in living samples works
in the same way. Using a laser guide, aberrations that distort the light’s path are revealed
and corrected by the microscope. There’s several examples where we’ve worked with some
of the biologists, and showed them a few of our samples. Their reactions have typically
been, “Even though I’ve been studying this for a decade, it’s as if I’m looking at this
for the first time.” And that is always inspiring. Even just talking about this is giving me
goosebumps. With such promising feedback from biologists, Gokul and his
team of instrumentation scientists and computational experts are taking that technology one step
further in a newly created imaging center in Berkeley. This is unlike any microscope
you may have seen in high school. Its purpose is to shed light on molecular mechanisms that
are either poorly understood or not understood at all. MOSAIC is the Swiss army knife microscope,
as we have called it during development. And the reason we’ve called it the Swiss army
knife is because when we were trying to miniaturize the adaptive optics with lattice light sheet,
we realized that all of the components that go into building that microscope can be repurposed
to build a completely different microscope. MOSAIC combines about seven to 10 different
imaging modalities into one microscope. You can reconfigure or transform the microscope
from one mode into another mode. Such that you can interrogate your sample using different modalities. We’ve imaged everything from live
imaging, also everything that’s dead as well. Cells didn’t evolve in isolation. Cells didn’t
evolve on a cover slip. The goal of this whole project was to see, hey, can we create a tool
that will allow biologists to be able to look at their particular processes in a more physiological,
more natural environment. For you to have an effect in medicine and other fields, you need to understand to be able to perturb, mitigate and or intervene, right?  And that’s
basically what this is doing. This instrument is going to be laying the groundwork in order to help understand how a virus enters a cell. For instance, if
you can understand the mechanism by which it’s
fusing to the plasma membrane and then injecting its contents into the cell, you now have the
ability to intervene. The team behind MOSAIC has already built one instrument, and is in
the process of bringing a second one online. The next step will be opening up the instrument
to biologists. Because the thing is we can only get so far by ourselves. The goal is
to make sure folks that have the ability to have the impact, we want to make sure we break
the barriers down. Whether it’s access to instrument time, whether it’s access to computational
resources or working with the computational biologists. With tools like these soon coming
online, biologists like Susanne are excited about the next decade of cell biology. We
basically have a little alien world that none of us can wrap our minds around, and it’s
all of these technologies that are allowing us to start to do that more intuitively. Imagine
a world where you could look at a cell and you know what it’s doing, what it has done
and what it will do. That means that you could collect a pathological specimen, and without
too much perturbation or staining collect a whole bunch of information and features
just from the image, that let a pathologist know something about the prognosis of the
disease and the mechanism of why that’s the case. There will of course be more and more
innovation. That’s always how it works, but this set of innovation is going to get translated
into useful results for everyone. There’s literally trillions of inanimate molecules
inside of cells that work together somehow to create life. That’s basically what thousands
of scientists around the world are trying to understand is how life works. We want
to watch the dynamics, the interplay between these molecules in order to really understand
the complexity, understand the beauty of what is happening within the cells. Biology is
probably one of the last human forefronts. It’s the age of exploration again, but instead
of looking out at the galaxies, we’re looking at the galaxies inside of the cells.

100 thoughts on “Your Textbooks Are Wrong, This Is What Cells Actually Look Like

  1. Hi Seekers, thanks for watching! Want more on the ever-changing world of microscopy? Check out this Elements on the world's first MRI of a single atom: https://youtu.be/pjiD0FrUNN8

  2. Absolutely beautiful. I always felt what we were taught in our flawed school system was complete crap. Huge leap forward, good or bad? I guess we will find out.

  3. I once heard someone say that science disproved God to them. I am just the opposite. The more I learn about science the more certain I am that God must be real.

  4. Excuse me when I looked through a microscope i saw a blob. Sorry we never had your $2000000000000000000000 microscope lol

  5. Wow. This is amazing. Our advances with microscopy, is expanding our knowledge of microbiology.

    And these were immune cells being showcased with so much complexity. I can just imagine how nerve cells, or neurons is depicted. The nervous system governs the entire organism.

  6. Can't leave well enough alone. Shoot had a way of back firing as you manage to piss off a very real CREATOR. You'll learn. The hard way. Like us, you won't like it one bit and it'll be all your own damn fault. They've been warned. They'll see.

  7. Our old textbooks are drawn based on 2d observation on an electron microscope. So this one its just 3d imagining rendering in a 3d microscope. 🤔

  8. So basically, God is real. Because evolution can not do this. An intelligent designer had to of made this. God is king, judge, savior and executioner.

    Roman's ch 1 ver 20 "For the invisible things of him from the creation of the world are clearly seen, being understood by the things that are made, even his eternal power and Godhead so that they are without excuse"

  9. Videos like this give me hope for humanity after listening to the awful local news every night. Seriously, videos like this should be required viewing in high school so our future scientists can start pondering Relevant issues and possible solutions. I cant remember learning about any environmental issues in school.Or even how to handle a credit card responsibly. Nothing useful. Anyone here use polynomial factoring in their daily life? How about from reading those "required reading" books like Catcher in the Rye, Of Mice and Men? Outside of academia word? Teachers please put your hands down, your considered Academia.

  10. Of course its not. You expect grade schoolers to understand cell structures in 3d format illuminated by fluorescent immunoassays?

    Of course they'll simplify it in text books.

    Also, it rubs me the wrong way that the narrator and the creator imply that he found the "true way" to look at cells and this is the only way to look at cells.

    No it's not, he just discovered a better and more expensive way to view cells but that doesn't invalidate cells in H&E preparations or the ones in Electron microscopes. His way is just a new way of looking at a cell.

  11. Cells look like the Universe. What if our Universe is one cell of an organism? And inside our cells are Billions of Universe.

  12. “There are literally trillions of inanimate molecules inside of cells that work together somehow…”

    I always find it funny how everyone puts all their faith in “science” and believe we know so much “facts” about how life and the universe has “evolved” and works.
    But you can look back over the last 100 years and everything that was “fact” about what “science” knew changed every decade or so when we took a step forward in technology.
    Then all of the sudden what was “fact” is no longer correct.
    I hear interviews all the time where a scientist says, “With this new technology we now know we were wrong about….”
    It wouldn’t bother me if they would teach things in a way that were not presented as fact and say something like, right now this is what we believe and this is how we interpret the data but that can and probably will change.
    I hate when people try to argue a point about life and say, “science says…”

    “Science doesn’t say anything,
    scientist do.”
    ~ Frank Turek

  13. Damn… what if we are just little things inside a cell which is inside a bigger organism 🧐🤔🤷🏽‍♀️ hits bong

  14. Well anyone for a class action lawsuits, I think it's time the Zionist liars paid for there deception, oh I mean the liar Jews.

  15. Excellent! I'm facinated!
    I am perplexed at the ignorance demonstrated by commenters!!? Obviously not all their brain cells are firing properly!!?

  16. I never get tired of watching this video. I can’t wait to see what’s next in cell microscopy. Perhaps a means to port this technique to any microscope anywhere? This is a great time to be alive!!

  17. I study Bio, but Microbio seems so bleak since the amount of labtime involved with that work seems soulcrushing. I’m personally moving in a more ecological/zoological direction, but I still find recent advanced in Bio fascinating regardless of what field it is

  18. This is incredible and I'm excited to see how I can implement this visualization of ehats occurring into my own physiological focus on my own body cells. This is fucken AWESOME!

  19. who have failed in exams and are going to, they'll have a better chance of learning better or they're in a infinite loop like cell's 🤯

  20. Finally. Now, can you use this to show the world what happens when you add flouride to drinking water and toothpaste, essentially when flouride enters the body and chemically reacts with bones and the brain for instance?

    Maybe you can finally get my greedy stupid country to remove this poison permanently. Cheers!

  21. Thanx ones again Seeker for the chance to share ideas with us. As i sayed in my first comment of the video THE FLOWER OF LIFE OR DNA DECODED is a video speaking of a round picture found in you tube in DNA PHOTOGRAPHI BY X RAY DEFRACTION the picture shows ENTANGLEMENT. Such a figure is made by 7 circles same as the flower of life where 6 of them encircle one at the meadle, the figure contains 4 hexagonals that each one stands for a color or a density each hexagonal is an orbit, from out is RED, YELLOW and BLUE and this 3 colors make white that as the way it moves so will the others that is why I say that we dont need of DARK ENERGY nither of DARK MATTER; the entanglement is done CROSS SECTION FROM NORTH TO SOUTH and vice versa as it must to be resiprocrate atraction and is the entanglement to me part of the things that dont let the stars to flye away in the galaxies been a form for matter to stick togather, if you add each pair entangled all of them add up the same say if red is 13Hz in one pair all of the other pairs add up 13 in same orbit and if yellow is 43 all add 43; the figure shows that all circles are jointed one to the other by a overslapping from one to another even if they are same charge since all the north side are positive and the south negative and this is another thing that make a stronger sticking to matter or galaxies; now if we call the CMB that makes a centripetal force making a push from all around to matter reinforces the union of matter pluss if we consider that matter follows ATOMIC WEIGHT and at the center of any system: atoms, cells, clusters of cells, planets, stars, galaxies etc. there is always a disc that both masses the solids and the gaseous make, this disc is posible to see it even in dna and is in this disc were the planets orbit so practicly the planets float in this disk in the same way following atomic weight even whene they atract one to another in entangled atraction that atract from rocky ones to gaseous ones always the very inside planet goes with the very out side one as follows in pairs: MERCURY- NEPTUNE, VENUS-URANUS, EARTH- SATURN and for last MARS-JUPITER and is not posible for planets to colaps because the south side that are rocky cant go up to south and vise versa. So with this 4 factors it is enough to me to keep matter togather in their respective places; the center of entanglement is the sun that is the center of all entangled planets.

    The above description bellongs to NOT BROKEN SYSTEMS that could be light or solar systems, THE BROKEN SYSTEM will be described in another commet cause Iam out of time.

    Thanx Seeker for such a good video help us to get well informed is a plasure to joy this kind of info very pleased.

  22. Imagine this technology combined with VR, so cell researchers can 'dive' into the cell dan even zoom in the cell world

  23. Wait but this Is all an accident….. Look at the glory of God people and this is only the stuff we can't see! Give your life to Jesus it's the best ever!

  24. Let’s be real. Once man fully understands the cells with this method they will find a way to destroy and alter cells. It sounds nice now how they are describing it in the video but you know good and evil will come from this knowledge.

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